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Plausibility and parameter sensitivity of micro-finite element-based joint load prediction at the proximal femur
AuthorSynek, Alexander ; Pahr, Dieter H.
Published in
Biomechanics and Modeling in Mechanobiology, 2018, Vol. 17, Issue 3, page 843-852
PublishedSpringer Nature, 2018
Document typeJournal Article
Keywords (EN)Micro-finite element / Inverse remodelling / Load estimation / Sensitivity / Femur
URNurn:nbn:at:at-ubtuw:3-4938 Persistent Identifier (URN)
 The work is publicly available
Plausibility and parameter sensitivity of micro-finite element-based joint load prediction at the proximal femur [2.28 mb]
Abstract (English)

A micro-finite element-based method to estimate the bone loading history based on bone architecture was recently presented in the literature. However, a thorough investigation of the parameter sensitivity and plausibility of this method to predict joint loads is still missing. The goals of this study were (1) to analyse the parameter sensitivity of the joint load predictions at one proximal femur and (2) to assess the plausibility of the results by comparing load predictions of ten proximal femora to in vivo hip joint forces measured with instrumented prostheses (available from www.orthoload.com). Joint loads were predicted by optimally scaling the magnitude of four unit loads (inclined 20 to 100 with respect to the vertical axis) applied to micro-finite element models created from high-resolution computed tomography scans (30.3 m voxel size). Parameter sensitivity analysis was performed by varying a total of nine parameters and showed that predictions of the peak load directions (range 1030) are more robust than the predicted peak load magnitudes (range 2344.84689.5 N). Comparing the results of all ten femora with the in vivo loading data of ten subjects showed that peak loads are plausible both in terms of the load direction (in vivo: 18.22.0, predicted: 20.0) and magnitude (in vivo: 2707.6443.3 N, predicted: 3372.2597.9 N). Overall, this study suggests that micro-finite element-based joint load predictions are both plausible and robust in terms of the predicted peak load direction, but predicted load magnitudes should be interpreted with caution

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