This master thesis deals with the different methods of earthquake calculation and their application to structures in areas with a high earthquake risk. The Introduction provides a general overview of the topic of earthquakes, examining the theoretical basics from the seismological and engineering seismological point of view, as well as the basics of earthquake calculation. The second chapter presents the most important parts of the EN 1998-1 () for shear walls with high ductility requirements. Additionally, this chapter introduces selected parts of the American concrete standard, the ACI 318M-11 () and the Iranian National Seismic Standard No. 2800 (). The linear and nonlinear seismic calculation methods that were used during this study are described in the new European Earthquake Standard, EN 1998-1. While the non-linear calculation methods have been implemented in the United States for a long time, they are not yet prevalent in European practice. This thesis seeks to compare the frequently used linear force-based methods with the more precise, yet more elaborate non-linear methods. In addition, the current thesis introduces methods for the simplification of complex buildings for the earthquake calculation. The results of the partial model are then compared with the results obtained on a 3D spatial model. The calculation is based on data from a hospital building, built in an area with a high earthquake risk. The data were provided by the company Werner Consult Ziviltechniker GmbH, for the preparation of this master thesis. The most important parameters of the earthquake calculation are determined and compared in the case of each presented calculation method. The results show that the nonlinear methods allow a far more accurate mapping of the building deformations and lead to more conservative and accurate shear forces. Finally, the reinforcement details, determined for the construction of the hospital building, were verified with a strut and tie model for the selected shear wall.