In the years since its foundation in 2010, the Edmond J. Safra Research Lab has produced numerous studies that established and extended definitions of Institutional Corruption and analyzed some cases of its occurrence. Institutional Corruption can be defined as a systemic influence on an institution. This influence is legal or currently accepted as ethical; however, it prevents an institution from fulfilling its socially defined purpose, and in the process, undermines public trust in that institution. The idea of Institutional Corruption was proven to be broadly applicable to many domains. It can be viewed as a paradigm and as an issue of organizational design. By analyzing the features of Institutional Corruption and identifying the role that both information and communication technologies (ICT) and e-Government could play, this study is looking for a more general framework and expansion of the theory of Institutional Corruption. ^The aim of this paper is to approach Institutional Corruption from multidisciplinary lenses, such as organizational design, data analysis, ICT and e-Governance. We are interested in the definition of Institutional Corruption, to identify its enablers and key concepts, such as economy of influence, public trust, and institutional purpose. An investigation into the relationship between e-Government and corruption is performed; furthermore, the challenges and some of the ICT-enabled solutions, such as transparency, open government data, e-participation, and e-democracy, are reviewed and discussed, as presented in the literature. The relationship between e-Government and corruption in the European Union (EU) is also investigated by developing and testing an empirical model, based on different data sets, some of which were provided by Transparency Internationals and the United Nations. The model helps to evaluate the impact of e-Government on corruption in Europe. ^The emerging relationship between inequality and corruption in the literature is also tested in the model. Thereafter, the theoretical fundament is applied to a case study about the health-care industry in the EU and off-label prescription. Furthermore, the existing databases and e-Government systems related to the clinical trials and market authorization of new drugs are presented, and a new e-Government system is proposed to assist various stakeholders in identifying and tracking off-label prescription, as well as to increase transparency and restore patients trust in new medicines, the industry, and the respective regulatory agencies at national and EU levels.