Homogeneous catalysis has numerous attractive features concerning selectivity and activity; however, catalyst, product and solvent removal after the reaction could lead to problems for the applicability in chemical industries. The concept of supported ionic liquid-phases (SILP) allows immobilizing a catalyst dissolved in ionic liquids as a thin layer on a porous solid support material, aiming to combine advantages of homogenous and heterogeneous catalysis. This SILP concept already found applications in gas phase reactions, while the use of a liquid mobile phase remains challenging due to ionic liquid and catalyst leaching. These problems may be overcome in combination with supercritical carbon dioxide (scCO2) as solvent, which shows high solubility in many ionic liquids, whereas ionic liquids typically only show limited solubility in scCO2. Reactants can be efficiently transported to the catalytic sites in the ionic liquid layer and products are afterwards removed from this phase in a continuous-flow methodology. This thesis focuses on the development of continuous-flow asymmetric Aldol and Mannich reactions in scCO2 relying on supported chiral ionic liquids as catalysts. A set of three different (L)-proline-based chiral ionic liquids was selected as organocatalysts for these two reactions, and the impact of operational conditions was investigated. Furthermore, studies on ionic liquid leaching were performed and showed that amino-acid derived ionic liquids can be immobilized as a thin layer on a solid silica support with minimal losses in a continuous flow system relying on scCO2 and acetone as solvent.