Incurable diseases represent a dramatic turning point in the lives of people affected. After the first medical diagnosis, the periods of consecutive time spent at home gradually decrease. The development of gradually deteriorating health condition is leading to more frequent, expensive stays in hospital. This is predominantly caused by inadequate medical care at home, often in combination with the progress of the disease. Furthermore, patients are challenged to cope with a variety of new challenges. Under such circumstances a reduction in quality of life is hardly avoidable. Intensifying of medical outpatient care seems to be a logical consequence. Yet, providing a permanent home care by medical personal is unrealistic in terms of feasibility and cost. However, improvement in medical care can be achieved through the use of telemedicine. In order to improve communication and documentation in the field of mobile care of seriously ill patients a user-centered design process was applied. In collaboration with physicians and patients the requirements, the concept and an initial prototype implementation of a patient-centered telemonitoring system was developed. Our prototype offers a first glimpse into a possible implementation of a patient's driven documentation and monitoring system. The gathered information further provides a good overview of requirements for corresponding systems. The results of this study are providing a cornerstone for future developments in the field of mobile telemedical care, where communication between doctor and patient via new media is of particular importance.