Hepatocellular carcinoma (HCC) is a severe disease of the hepatocytes (liver cells). Patients with intermediate HCC (locally advanced without metastasis) receive palliative local treatments, such as the trans-arterial chemoembolization (TACE) or the Selective Internal Radiation Therapy (SIRT). This therapy, utilizing small radioactive spheres, has shown promising results in prolonging the life expectancy of patients with unresectable HCC. These particles irradiate the tumor on the one hand, and block in the case of the usage of SIR-Spheres® the tumor capillaries on the other hand, yielding in "starvation" of the tumor and, therefore, a deceleration of its progression. An important requirement for patients considering this therapy is the assessment of the hepatopulmonary shunting. Shunts facilitate access from the liver to other organs, so that particles may dislocate, causing severe damages. The evaluation is performed by a technetium (99mTc) albumin aggregated (MAA) scan, where, similar to SIRT, small radiative spheres are injected into the hepatic artery. 99mTc emits 140 keV gamma rays which can be detected by Single Photon Emission Computed Tomography/Computed-Tomography (SPECT/CT). In addition, MAA-SPECT allows also a quantitative estimation of the tumor volume, which is highly vascularized and, therefore, well blood perfused. The assumption that patients with tumors, which are highly vascularized, profit from SIRT, was the motivation of this thesis. A volumetric analysis should assist in the future the selection of possible candidates for SIRT and improve their prognosis. The aim of this thesis was the volumetric analysis of 24 patients with HCC. The vascularization of the liver was determined by MAA-SPECT/CT. The metabolic volume was determined by a Fluoroethylcholine Positron-Emission-Tomography/Computed-Tomography (FEC-PET/CT). The combined volumes of vascularization and metabolism result in a volume which is highly metabolized and vascularized. These computations were analyzed and compared with the survival data (remaining days after FEC-PET/CT till death) and the tumor marker Alpha-fetoprotein (AFP) before and after the SIRT of each patient, respectively. The results of this study suggest that patients with smaller tumor volumes have by trend an increased median survival. Receiver Operating Characteristic analyses (ROC) have shown that patients with a metabolic volume, which is highly vascularized, have a poorer prognosis in comparison with patients with low-vascularized metabolic-active tumor volumes. A multiple logistic regression analysis, comprised of several parameters confirms these results. However, these individual factors except of the metabolic tumor volume are not significant presumably due to the small number of patients. The ROC-analyses from the AFP-values were not significant in this study, again due to the low number of patients. Investigations with more patients are required for a quantitative conclusion, yet, the present thesis shows the potential of this volumetric analysis regarding prognosis and life expectancy of HCC patients.