The discipline of building climatology, which emerged during the first half of the 20th century, combines knowledge in architecture, civil engineering, physiology, meteorology, and physics. It aims at exploring the thermal properties of buildings and the human reaction to thermal conditions created and affected by buildings. Upon its emergence, building climatology implicitly suggested an alternative design methodology in which design decisions could be based on scientifically-sound and quantitative (instead of qualitative) parameters, including parameters which define the desired thermal characteristics of buildings ("indoor climate") and their surroundings ("outdoor climate"). The new discipline has produced an impressive body of knowledge which could have helped architects to scientifically optimize the response of their buildings to climatic conditions. Nevertheless, it can be argued that architects at large still neglect the rich scientific knowledge and tools created by building climatology, failing to integrate them into the design of buildings. Keeping in mind the magnitude of research efforts that were invested in building climatology for more than half a century, it is thus important to look into this failure and to understand its causes and effects. The current study explores the relation between architectural practice and building climatology research in Israel from the beginning of the 1940's up to the mid-1970's. Israel is an excellent example for a country in which building climatology was rapidly developing because of a pressing need to resolve recurrent climatic failures of common design and building methods, and especially in meeting the challenges of its hot season. A scientific field established almost exclusively by Jewish émigrés from Germany, Israeli building climatology, which received a long-standing support from the country's Ministry of Housing, was developing during the 1960's and 1970's to gain international recognition for its scientific achievements. In spite of its expanding body of knowledge and its impressive scientific level, the effect of Israeli building climatology on local architecture practices was minimal, even in times when local architects continued to express their concern over the climatic aspects of building. This discrepancy reflected some basic flaws in the way the emerging science has been understood, interpreted, and applied by local architects. The overall tendency was clear: as scientific research became more and more elaborate and detailed, architects were less and less open to exploit its products in a sincere and rigorous manner. A multi-disciplinary approach for conceptualizing and analysing the relation between architecture and building climatology, based on the Israeli case, is employed in the current study. It first unfolds the history of building climatology research in Israel, its struggles, achievements, and reception among local architects, and then analyses three case studies (the Gilman Building in Tel Aviv, the Model Housing Estate in Be'er Sheva, and the Eshkol Tower in Haifa), each one representing different design habits and approaches towards scientific knowledge, by coupling historical research with the analysis of the buildings' climatic performance. The integration of different research and analysis methods enables to extract a multi-faceted depiction of the relations between climatic research and architecture, and to conclude that building climatology in Israel has been developing as a separate body of knowledge which was never fully accepted or even partially absorbed within the repertoire of local architectural know-how, practices, and techniques. In the few cases where building climatology knowledge was employed by informed architects during all stages of design, the results proved to be satisfactory. On the other hand, the majority of Israeli architects were reluctant to acquire the needed expertise in building climatology or even to cooperate with experts in the field, making the impact of building climatology research on the performance of local buildings limited and partial, if existing at all.