The connection of the different aspects in the process of virtual product development offers new potential for innovation and efficiency. For instance, the combination of Computer-Aided Design (CAD) and physical systems simulation helps analysing the effects of a component on the entire system in the design stage. This idea requires advanced approaches in computational engineering, for example through Cooperative- Simulation (Co-Simulation). In this context the main goal of this study is to investigate the possibilities of Co-Simulation with CATIA V6 Dynamic Behavior Modeling. Starting with the basic principles of acausal, object-oriented modeling with Modelica, methods of implementing a Co-Simulation are discussed. Two different approaches for integrating CATIA V6, especially with regard to accessing the geometry data of CAD models, are presented and assessed. By examining methods of implementation, simulation errors and flexibility of simulator choices, the Building Controls Virtual Test Bed (BCVTB) is preferred to the Functional Mockup Interface (FMI). To ensure efficient computation, a method for parallelisation of a Co-Simulation is investigated. As an example, the model of a motor vehicle demonstrates the possibilities of Co-Simulation in connection with CATIA V6. The application of the Modelica language allows an object-oriented description of mechanical components. Special attention is paid to the model of the wheel, specifically on the flexible usage with regard to the whole automobile. The engine is implemented as a data-based model in MATLAB, based on its characteristic behaviour. The main gear box is incorporated by inclusion of the transmission ratios. The selection of the gear can be represented as a state chart in Stateflow. Various scenarios are simulated and the behavior of the model with the pros and cons of the chosen approaches are discussed. The possibilities and limitations of the applicability of the model are shown. With the presented methods, future potential of using Co-Simulation with CATIA V6 for virtual product development arises.