This thesis document intends to answer the questions of "What are the current challenges facing entrepreneurship in Egypt? And what are the suitable actions to boost entrepreneurship in the country?" To answer these questions, the author's work builds on available data to assess the current situation, identify the challenges, and filter expert recommendations in the context of boosting entrepreneurship in Egypt through proposing suitable action points. The document starts with a literature review of relevant theoretical content to the topic. The intention is to present a framework for measuring entrepreneurship, explain related indexes, and provide an overview of the concept of entrepreneurship ecosystem. Then a situation analysis is conducted. The situation analysis outcome revealed many opportunities to overcome the challenges facing entrepreneurship in Egypt. As a first step of the solution, a framework for instilling an entrepreneurship ecosystem is overviewed with clear objectives set and sample map to visualize all related items provided. This is followed by the presentation of key roadmap initiatives that would address challenges in areas like; improving access to finance, increasing average level of education in general and entrepreneurship education in particular, support female entrepreneurship, boost R&D and technology usage, spread awareness to overcome cultural issues impacting entrepreneurship, introduce entrepreneurship-friendly policies and increase government support, and enhance infrastructure that facilitates entrepreneurship. These particular initiatives are proposed based on one or more of the following selection criteria: (1) directly addressing the challenges that were highlighted by the situation analysis, (2) enhance/complement/complete items of the entrepreneurship ecosystem, (3) recommended as best practice by international organizations to foster entrepreneurship, and (4) represent a success story after implementation in other countries. Finally, the author concludes by listing areas of further research that would build on this thesis work and expand the scope to include more detailed implementation plans for each of the suggested initiatives and action points with detailed timelines and costs.