During the last centuries there was one specific survival mechanism that proofed itself worthful. In further context we will talk about that survival mechanism, namely fever, and refer to it as -heat-shock-. Due to the rise of temperature above the usual physiological body temperature a specific reaction is triggered in the cells. An increased amount of heat-shock-proteins is produced to reestablish the state of equilibrium of the cell. If errors or incomplete sequences occur during this cascade, the faults can lead to different severe diseases or become parts of such diseases. Besides a changed expression of proteins or a raised production of heat-shock-proteins, further intracellular and extracellular effects during and after a heat-shock can be observed. In this thesis changes of the outer side of the plasmamembrane and an intracellular feedback of modified chinese-hamster-ovary cells affected by a heat-shock are examined. The cells are hereby furnished with a glycosylphosphatidylinositol-anchor with a green fluorescent protein. With the aid of special application possibilities of the fluorescence microscopy the stability of nanoplatforms on the outer cellmembrane in the case of physiological and elevated temperatures is investigated. Thereby the time course of nanoplatforms as well as the surface density, the expression level and the mobility of GFP-GPI-molecules affected by a heat-shock are visualized. To check for an intracellular answer, the time course of the Ca2+-signal is analyzed for different heat-shock-scenarios. By comparing the intracellular and extracellular reactions, a possible explanation for those heat-shock-effects is given.