<div class="csl-bib-body">
<div class="csl-entry">Le Muzic, M. (2016). <i>From atoms to cells: interactive and illustrative visualization of digitally reproduced lifeforms</i> [Dissertation, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2016.33787</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2016.33787
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/6402
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dc.description
Zusammenfassung in deutscher Sprache
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dc.description.abstract
Macromolecules, such as proteins, are the building blocks of the machinery of life, and therefore are essential to the comprehension of physiological processes. In physiology, illustrations and animations are often utilized as a mean of communication because they can easily be understood with little background knowledge. However, their realization requires numerous months of manual work, which is both expensive and time consuming. Computational biology experts produce everyday large amount of data that is publicly available and that contains valuable information about the structure and also the function of these macromolecules. Instead of relying on manual work to generate illustrative visualizations of the cell biology, we envision a solution that would utilize all the data already available in order to streamline the creation process. In this thesis are presented several contributions that aim at enabling our vision. First, a novel GPU-based rendering pipeline that allows interactive visualization of realistic molecular datasets comprising up to hundreds of millions of macromolecules. The rendering pipeline is embedded into a popular game engine and well known computer graphics optimizations were adapted to support this type of data, such as level-of-detail, instancing and occlusion queries. Secondly, a new method for authoring cutaway views and improving spatial exploration of crowded molecular landscapes. The system relies on the use of clipping objects that are manually placed in the scene and on visibility equalizers that allows ne tuning of the visibility of each species present in the scene. Agent-based modeling produces trajectory data that can also be combined with structural information in order to animate these landscapes. The snapshots of the trajectories are often played in fast-forward to shorten the length of the visualized sequences, which also renders potentially interesting events occurring at a higher temporal resolution invisible. The third contribution is a solution to visualize time-lapse of agent-based simulations that also reveals hidden information that is only observable at higher temporal resolutions. And nally, a new type of particle-system that utilize quantitative models as input and generate missing spatial information to enable the visualization of molecular trajectories and interactions. The particle-system produces a similar visual output as traditional agent-based modeling tools for a much lower computational footprint and allows interactive changing of the simulation parameters, which was not achievable with previous methods.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
molecular rendering
en
dc.subject
illustrative visualisation
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dc.subject
visual computing
en
dc.subject
multi-scale visualisation
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dc.subject
real-time visualisation
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dc.subject
physiology visualisation
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dc.subject
cell physiology
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dc.title
From atoms to cells: interactive and illustrative visualization of digitally reproduced lifeforms
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dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2016.33787
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Mathieu Le Muzic
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dc.publisher.place
Wien
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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tuw.publication.orgunit
E186 - Institut für Computergraphik und Algorithmen
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dc.type.qualificationlevel
Doctoral
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dc.identifier.libraryid
AC13387791
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dc.description.numberOfPages
102
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dc.identifier.urn
urn:nbn:at:at-ubtuw:1-91383
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dc.thesistype
Dissertation
de
dc.thesistype
Dissertation
en
dc.rights.identifier
In Copyright
en
dc.rights.identifier
Urheberrechtsschutz
de
tuw.advisor.staffStatus
staff
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item.fulltext
with Fulltext
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item.cerifentitytype
Publications
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item.mimetype
application/pdf
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item.openairecristype
http://purl.org/coar/resource_type/c_db06
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item.languageiso639-1
en
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item.openaccessfulltext
Open Access
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item.openairetype
doctoral thesis
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item.grantfulltext
open
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crisitem.author.dept
E186 - Institut für Computergraphik und Algorithmen