<div class="csl-bib-body">
<div class="csl-entry">Steinbauer, P. (2018). <i>RAFT polymers for tissue regeneration</i> [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://doi.org/10.34726/hss.2018.41868</div>
</div>
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dc.identifier.uri
https://doi.org/10.34726/hss.2018.41868
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/3029
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dc.description.abstract
The number of patients with minor and major accidents coming into accident and emergency care is steadily rising due to increasing life spans and the aging of our society. In order to ensure efficient care and health of human beings, medical methods need to be optimized. The fixation and adhesion between tissues, implants or scaffolds have to be refined, but the number and versatility of biomimetic and biocompatible adhesives that can be used for such purpose is limited. In the last few years studies of phosphorus-based polymers have attracted attention because of their large variety of applications. In the field of adhesion promotors and tissue engineering they have been subject of great interest. These phosphorus-based materials are proved to be biodegradable, blood-compatible and led to strong interactions with bones, enamel or dentin. The problem in measuring the adhesion properties of bone glue is to distinguish between cohesive and adhesive behavior and little information is known from processes at the molecular level. In this thesis, new approach is to measure the adhesion via single molecule force microscopy (SMFM). Therefore, AFM tips had to be functionalized to investigate the adhesion of two amino acid sequences, of a dopamine compound and of the adhesive block copolymers on different substrates. We were interested in the development of such polymers for adhesion properties. Therefore, phosphorus-containing methacrylates were polymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization. This polymerization technique had proved to be a highly versatile and widely applicable living radical polymerization method. It allows the synthesis of well-defined polymers with different architectures. Hence, it is possible to form a narrow distributed block copolymer. These block copolymers can bind to hydroxyl, carboxylic or amino groups of the organic collagen of a bone and form complexes with Ca2+ ions in the inorganic components.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
RAFT Polymere
de
dc.subject
RAFT Polymers
en
dc.title
RAFT polymers for tissue regeneration
en
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.identifier.doi
10.34726/hss.2018.41868
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dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Patrick Steinbauer
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dc.publisher.place
Wien
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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dc.contributor.assistant
Baudis, Stefan
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tuw.publication.orgunit
E163 - Institut für Angewandte Synthesechemie
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dc.type.qualificationlevel
Diploma
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dc.identifier.libraryid
AC14532195
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dc.description.numberOfPages
153
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dc.identifier.urn
urn:nbn:at:at-ubtuw:1-107059
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dc.thesistype
Diplomarbeit
de
dc.thesistype
Diploma Thesis
en
tuw.author.orcid
0000-0003-3398-1231
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dc.rights.identifier
In Copyright
en
dc.rights.identifier
Urheberrechtsschutz
de
tuw.advisor.staffStatus
staff
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tuw.assistant.staffStatus
staff
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tuw.advisor.orcid
0000-0001-7865-1936
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tuw.assistant.orcid
0000-0002-5390-0761
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item.openaccessfulltext
Open Access
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item.grantfulltext
open
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item.cerifentitytype
Publications
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item.mimetype
application/pdf
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item.openairecristype
http://purl.org/coar/resource_type/c_bdcc
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item.languageiso639-1
en
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item.openairetype
master thesis
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item.fulltext
with Fulltext
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crisitem.author.dept
E163-02-1 - Forschungsgruppe Polymerchemie und Technologie