<div class="csl-bib-body">
<div class="csl-entry">Imran, F., Lück, R., Jordan, C., Herwig, C., & Harasek, M. (2023, October 25). <i>A Mini-Perspective on the Role of Digitalization Enablers in Sustainable Pharmaceutical Manufacturing</i> [Conference Presentation]. 2nd International Conference on Energy, Environment and Digital Transition, Palermo, Italy.</div>
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dc.identifier.uri
http://hdl.handle.net/20.500.12708/192287
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dc.description.abstract
Due to the steady rise in the implementation of Industry 4.0 concepts in chemical and (bio)pharmaceutical industries, an essential aspect of transitioning pharmaceutical production towards Sustainable Pharmaceutical Manufacturing (SPM) is the utilization of digitalization technologies. SPM involves the collaboration of a multitude of different process engineering and sustainability-oriented systems methodologies like Lifecycle Assessment and green metrics. Keeping this in mind, this paper aims to provide a concise review of critical areas of digitalization aspects to overcoming the hurdles towards sustainability of pharmaceutical processes: process analytical technologies (PATs), soft sensors and Digital Twins (DTs). These tools enable manufacturing under the Quality-by-Design (QbD) paradigm, prioritizing process and product understanding and yield to reduce the number of tests, resources, and costs in the long run. Modernization through DTs and PAT requires significant data exchange and a fully realized data management system. Successful integration of digitalization, I4.0, and lean manufacturing concepts have been found to be of substantial advantage for flexible supply chains and continuous manufacturing, higher efficiencies, and productivity with minimal waste production. The path to utilizing these tools to their full potential in the pharmaceutical industry is closely examined for application in specific processes and products in the future.
en
dc.description.sponsorship
European Commission
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dc.language.iso
en
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dc.subject
process intensification
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dc.subject
green metrics
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dc.subject
digitalization
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dc.subject
continuous biomanufacturing
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dc.subject
process monitoring & control
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dc.title
A Mini-Perspective on the Role of Digitalization Enablers in Sustainable Pharmaceutical Manufacturing
en
dc.type
Presentation
en
dc.type
Vortrag
de
dc.relation.grantno
101057844
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dc.type.category
Conference Presentation
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tuw.project.title
Toolbox der nächsten Generation zum umweltfreundlichen Design und Herstellung von Arzneimitteln bei geringer Umweltbelastung