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<div class="csl-entry">Kastberger, B. (2011). <i>Creating universality for cancer gene therapy in applying Adenovirus vectors with altered tropism : designing Adenovirus particles using K-Coil/E-Coil technology to control receptor specificity</i> [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-42163</div>
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For my Master Thesis project I was charged with the design of two recombinant types of adenoviruses. The first adenovirus should possess a K-coil sequence situated in the HI-loop region of the fibre's knob domain, the other one was supposed to have an ablated CAR tropism in addition to the identical K-coil insertion. The virus' transduction efficiency via EGF-receptors was monitored by fluorescents provoked by a GFP marker, that had to be inserted into the E1 region of the AdV genome for this reason.
en
dc.language
English
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dc.language.iso
en
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dc.rights.uri
http://rightsstatements.org/vocab/InC/1.0/
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dc.subject
Adenovirus
de
dc.subject
Gentherapie
de
dc.subject
K-Coil
de
dc.subject
E-Coil Technologie
de
dc.subject
Krebs
de
dc.subject
Biotechnologie
de
dc.subject
Tropismus
de
dc.subject
Car-Rezeptor
de
dc.subject
GFP-Marker
de
dc.subject
Adenovirus
en
dc.subject
Gene therapy
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dc.subject
K-Coil
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dc.subject
E-Coil Technology
en
dc.subject
Cancer
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dc.subject
Biotechnology
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dc.subject
Tropism
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dc.subject
Car-Receptor
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dc.subject
GFP-Marker
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dc.title
Creating universality for cancer gene therapy in applying Adenovirus vectors with altered tropism : designing Adenovirus particles using K-Coil/E-Coil technology to control receptor specificity
en
dc.type
Thesis
en
dc.type
Hochschulschrift
de
dc.rights.license
In Copyright
en
dc.rights.license
Urheberrechtsschutz
de
dc.contributor.affiliation
TU Wien, Österreich
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dc.rights.holder
Birgit Kastberger
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tuw.version
vor
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tuw.thesisinformation
Technische Universität Wien
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dc.contributor.assistant
Kubicek, Peter Christian
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dc.contributor.assistant
Gadek-Wesierski, Jozefa
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tuw.publication.orgunit
E166 - Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften